Georgopoulos,P.G.(200): A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water Air Soil Pollut: Focus, 8, 3-21.

『ホリスティック（全体論的）健康リスク評価枠組みにおける環境系と生物系の相互作用を評価するための多規模アプローチ』

『Abstract
　Advances in computing processing power and in availability of environmental and biological data have allowed the development and application of comprehensive modeling systems that utilize a holistic, integrated, approach for assessing the interactions of environmental and biological systems across multiple scales of spatiotemporal extent and biological organization. This approach allows mechanism-based environmental health risk assessments in a person-oriented framework, which accounts for simultaneous exposures to contaminants from multiple media, routes, and pathways. The conceptual basis and example applications of the Modeling ENvironment for TOtal Risk (MENTOR), and the DOse-Response Information ANalysis system (DORIAN) are presented.

Keywords: Comprehensive modeling systems; DORIAN; MENTOR; Environmental health; Risk assessments; Exposures to mixtures』

1. Introduction: The evolution of environmental risk assessment
2. The modeling environment for total risk studies (MENTOR)
3. The dose-response information analysis system (DORIAN)
4. Examples: Selected case studies
5. Conclusions
Acknowledgments
Appendix
References

Appendix
　Table 2 A representative subset of databases (with website reference) that are available for providing data for use in MENTOR applications (see http://www.ebKB.org for a more extensive list)

Table 3 A representative subset of databases (with website reference) that are available for providing data for use in DORIAN applications (see http://www.ebKB.org for a more extensive list)

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